Yes, this could indeed become a reality. Twilight actress Kristen Stewart has been offered the role of Kei in the big-budget live-action remake of Akira. I haven't seen any of the Twilight movies, but I know just having the ties to that series is going to be enough for people to dislike her in the role of Kei.
What do you guys think about the casting decision? Keep in mind that nothing is official at this time, and no deal has been made. It's just the way things are being approached right now.